Selected Publications

U'Ren, J.M., Schupp, J.M., Pearson, T., Hornstra, H., Friedman, C.L.C., Smith, K.L., Daugherty, R.R.L., Rhoton, S.D., Leadem, B., Georgia, S., Cardon, M., Huynh, L.Y., DeShazer, D., Harvey, S.P., Robison, R., Gal, D., Mayo, M.J., Wagner, D., Currie, B.J., and Keim, P. 2007. Tandem repeat regions within the Burkholderia pseudomallei genome and their application for high resolution genotyping. BMC Microbiol. 7:23.

Schell, M.A., Ulrich, R.L., Ribot, W.J., Brueggemann, E.E., Hines, H.B., Chen, D., Lipscomb, L., Kim, H.S., Mraze, J., Nierman, W.C. and DeShazer, D. 2007. Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol. Microbiol. 64(6):1466-1485.

Romero, C.M., DeShazer, D., Feldblyum, T., Ravel, J., Woods, D.E., Kim, H.S., Yu, Y., Ronning, C.M., and Nierman, W.C. 2006. Genome sequence alterations detected upon passage of Burkholderia mallei in culture and in mammalian hosts. BMC Genomics. 7:228.

Parthasarathy , N., DeShazer, D., England, M., and Waag, D.M. 2006. Polysaccharide microarray technology for the detection of Burkholderia pseudomallei and B. mallei antibodies. Diagn Microbiol Infect Dis. 1(1): 162-169.

Choi,K-H., DeShazer, D., and Schweizer, H.P. 2006. Mini-Tn7 insertion in bacteria with multiple attTn7 sites: example Burkholderia mallei ATCC 23344. Nature Protocols. Nat. Protocols. 1(1): 162-169

Yu, Y., Kim, S., Hoon, C.H., Rodrigues, F., Daoxun, L., Hoon, S.S., Derr, A., Engels, R., DeShazer, D., Birren, B., Nierman, W., Tan, P. 2006. Genomic patterns of pathogen evolution revealed by comparison of Burkholderia pseudomallei, the causative agent of melioidosis, to avirulent Burkholderia thailandensis. BMC Microbiology. May 26;6(1):46.

Ulrich, R.L., Ulrich, M.P., Schell, M.A., Kim , H.S., and DeShazer, D. 2006. Development of a PCR Assay for the Specific Identification of Burkholderia mallei and Differentiation from Burkholderia pseudomallei and Other Closely Related Burkholderiaceae. Diagn Microbiol Infect Dis. 55: 37-45.

Kim, H.S., Schell, M.A., Yu, Y., Ulrich, R.L., Nierman, W.C., and DeShazer, D. 2005. Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies. BMC Genomics. 6:174.

Stevens, J.M., Ulrich, R.L., Taylor, L.A., Wood, M.W., DeShazer, D., Stevens, M.P., and Galyov, E.E. 2005. Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant. J. Bacteriol. 187: 7857-7862.

Ulrich, R.L., Amemiya, K., Waag, D.M., Roy, C.J., and DeShazer, D. 2005. Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice. Vaccine. 23: 1986-1992.

Waag, D.M. and DeShazer, D. 2004. Glanders: New Insights Into an Old Disease, p. 209-237. In L.E. Lindler, F.J. Lebeda, and G.W. Korch (ed.), Biological Weapons Defense: Infectious Diseases and Counterbioterrorism. Humana Press Inc., Totowa, NJ.

Ulrich, R.L., DeShazer, D., Brueggemann, E.E., Hines, H.B., Oyston, P.C., and Jeddeloh, J.A. 2004. Role of quorum sensing in the pathogenicity of Burkholderia pseudomallei. J. Med. Microbiol. 53: 1053-1064.

Ulrich, R.L., DeShazer, D., Hines, H.B., and Jeddeloh, J.A. 2004. Quorum sensing: a transcriptional regulatory system involved in the pathogenicity of Burkholderia mallei. Infect. Immun. 72:6589-6596.

Nierman, W.C., DeShazer, D., Kim, H.S., Tettelin, H., Nelson, K.E., Feldblyum, T., Ulrich, R.L., Ronning, C.M., Brinkac, L.M., Daugherty, S.C., Davidsen, T.D., Deboy, R.T., Dimitrov, G., Dodson, R.J., Durkin, A.S., Gwinn, M.L., Haft, D.H., Khouri, H., Kolonay, J.F., Madupu, R., Mohammoud, Y., Nelson, W.C., Radune, D., Romero, C.M., Sarria, S., Selengut, J., Shamblin, C., Sullivan, S.A., White, O., Yu, Y., Zafar, N., Zhou, L., Fraser, C.M. 2004. Structural flexibility in the Burkholderia mallei genome. Proc Natl Acad Sci U S A. 101: 14246-14251.

Holden, M.T., Titball, R.W., Peacock, S.J., Cerdeno-Trraga ,A.M., Atkins, T., Crossman, L.C., Pitt, T., Churcher, C., Mungall, K., Bentley, S.D., Sebaihia, M., Thomson, N.R., Bason, N., Beacham, I.R., Brooks, K., Brown, K.A., Brown, N.F., Challis, G.L., Cherevach, I., Chillingworth, T., Cronin, A., Crossett, B., Davis, P., DeShazer, D., Feltwell, T., Fraser, A., Hance, Z., Hauser, H., Holroyd, S., Jagels, K., Keith, K.E., Maddison, M., Moule, S., Price, C., Quail, M.A., Rabbinowitsch, E., Rutherford, K., Sanders, M., Simmonds, M., Songsivilai, S., Stevens, K., Tumapa, S., Vesaratchavest, M., Whitehead, S., Yeats, C., Barrell, B.G., Oyston, P.C., Parkhill, J. 2004. Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A. 101: 14240-14245.

DeShazer, D. 2004. Genomic diversity of Burkholderia pseudomallei clinical isolates: subtractive hybridization reveals a Burkholderia mallei -specific prophage in B. pseudomallei 1026b. J. Bacteriol. 186: 3938-3950.

Moore, R.A., Reckseidler-Zenteno, S., Kim, H., Nierman, W., Yan, Y., Tuanyok, A., Warawa, J., DeShazer, D., and Woods, D.E. 2004. Contribution of gene loss to the pathogenic evolution of Burkholderia pseudomallei and Burkholderia mallei. Infect. Immun. 72: 4172-4187.

Ulrich, R.L. and DeShazer, D. 2004. Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei. Infect. Immun. 72:1150-1154.

Lopez, J., Copps, J., Wilhelmsen, C., Moore, R., Kubay, J., St-Jaques, M., Halayko, S., Kranendonk, C., Toback, S., DeShazer, D., Fritz, D.L., Tom, M., and Woods, D.E. 2003. Characterization of experimental equine glanders. Microbes Infect. 5:1125-1131.

Woods, D.E., Jeddeloh, J.A., Fritz, D.L. and DeShazer, D. 2002. Burkholderia thailandensis E125 harbors a temperate bacteriophage specific for Burkholderia mallei. J. Bacteriol. 184:4003-4017.

Amemiya, K., Bush, G.V., DeShazer, D. and Waag, D.M. 2002. Nonviable Burkholderia mallei induces a mixed Th1- and Th2-like cytokine response in BALB/c mice. Infect. Immun. 70:2319-2325.

Srinivasan, A., Kraus, C.N., DeShazer, D., Becker, P.M., Dick, J.D., Spacek, L., Bartlett, J.G., Byrne, W.R. and Thomas, D.L. 2001. Glanders in a military research microbiologist. N. Engl. J. Med. 354:256-258.

DeShazer, D., Waag, D.M, Fritz, D.L. and Woods, D.E. 2001. Identification of a Burkholderia mallei polysaccharide gene cluster by subtractive hybridization and demonstration that the encoded capsule is an essential virulence determinant. Microb. Pathog. 30:253-269.

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